ABSTRACT
Introduction: SARS - CoV mainly affects the airways and, although most cases of COVID-19 are mild or moderate, up to 30% of patients may have the severe form of the disease and be hospitalized due to the cytokine storm in response to viral infection (Milovanovic, L. et al. BMJ Open. 2021;11(1):e042008). Of these, up to a quarter need an Intensive Care Unit (ICU) and in this unit, data on partial pressure of oxygen (PaO2), carbon dioxide (PaCO2) and inflammatory markers are collected daily to assess respiratory function and assist in decision making. Aim(s): To analyze how these blood gas and inflammatory data are related to a greater need for invasive support and mortality in the ICU. Method(s): 79 patients admitted to an Intensive Care Unit with a mean age of 60 years, of whom 50 required invasive support and 44 died. Result(s): After comparing the groups, it was observed that the need for invasive ventilatory support and death were related to higher values of PaCO2 (p<0.001;p<0.001) and C-Reactive Protein (p=0.004;p=0.006), which did not occur with those with lower PaO2 levels (p=0.339;p=0.580). Furthermore, the inflammatory activity marker CRP correlated significantly and positively with PaCO2 (p=0.007;0.378), which did not happen with PaO2 (p=0.406;-0.121). Conclusion(s): Although the respiratory involvement caused by COVID-19 has hypoxemic characteristics, it is observed that, in critically ill patients, the assessment of CRP and carbon dioxide levels are more decisive for the clinical outcome, having more relevance for patient decisions and evaluations. serious hospitalized with COVID-19.